Potensi Ekstrak Daun Turi Merah (Sesbania grandiflora L. Pers) Sebagai Immunomodulator Pada Mencit (Mus musculus) Nifas yang Diinokulasi Streptococcus agalactiae

Authors

  • Heppy Rina Mardiana Program Studi S1 Kebidanan, STIKES Husada Jombang , Indonesia

DOI:

https://doi.org/10.31004/jptam.v6i1.3104

Keywords:

Turi merah, Immunomodulator, Mencit nifas

Abstract

Streptococcus agalactiae merupakan salah satu bakteri yang berperan terhadap terjadinya infeksi post partum selain Staphylococcus aureus. Tujuan penelitian ini mengetahui potensi ekstrak daun turi merah sebagai immunomodulator terhadap Mencit (Mus musculus) nifas yang diinokulasi Streptococcus agalactiae.Terdapat 4 kelompok mencit nifas yaitu : satu kelompok kontrol, dan tiga kelompok perlakuan dengan 3 dosis. Pemberian ekstrak daun turi merah pada kelompok perlakuan 2 jam setelah pemberian bakteri melalui oral dengan 3 dosis. Pengukuran kadar sitokin IL 6 menggunakan metode ELISA. Analisis menggunakan uji Kruskal-Wallis didapatkan (p < 0,05) dan uji |Ri-Rj| 5%. Hasil penelitian menunjukkan bahwa penurunan kadar sitokin proinflamasi IL 6 secara signifikan pada kelompok perlakuan (P2) dengan dosis 250mg/kgBB dan (P3) dengan dosis 500mg/kgBB. Zat aktif pada daun turi merah (flavonoid) mempengaruhi makrofag untuk menurunkan sitokin proinflamasi.

References

Abbas, A. K., Lichmant, A. H. 2015. Cytokines. In: Cellular and Molecular Immunology. 5^th. Ed. Philadelpia: W. B. Saunders Company.

Kemenkes RI. 2020. Profil Kesehatan Indonesia Tahun 2019. Jakarta : Kemenkes RI.

Mhalu. 2016. Infection With Streptococcus agalactiae In a London Hospital. London : Hammersmith Hospital W12.

Nazir, Nighat. Immunomodulatory Actifity OF Isoflavones Isolated From Iris Kashmiriana : Effect on T lymphosit Proliferation and Cytokine Production in Balb/c mice. 2013. India : Islamia College.

Yusniawati, Eva. 2015. Efek Antibakteri Ekstrak Etanol Daun Turi Merah Terhadap Staphylococcus aureus.

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Published

13-02-2022

How to Cite

Mardiana, H. R. . (2022). Potensi Ekstrak Daun Turi Merah (Sesbania grandiflora L. Pers) Sebagai Immunomodulator Pada Mencit (Mus musculus) Nifas yang Diinokulasi Streptococcus agalactiae. Jurnal Pendidikan Tambusai, 6(1), 1261–1265. https://doi.org/10.31004/jptam.v6i1.3104

Issue

Vol. 6 No. 1 (2022): April 2022

Section

Articles of Research

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