Efek Potensial Senyawa Curcumin sebagai Terapi pada Penderita Covid-19: Literature Review

Authors

  • Nur Rahmah Hidayati STIKes Muhammadiyah Tegal, Jawa Tengah, Indonesia
  • Ikrima Khaerun Nisa STIKes Muhammadiyah Tegal, Jawa Tengah, Indonesia
  • Arief Darmawan STIKes Muhammadiyah Tegal, Jawa Tengah, Indonesia
  • Fitrotun Nisa STIKes Muhammadiyah Tegal, Jawa Tengah, Indonesia

DOI:

https://doi.org/10.31004/jptam.v5i3.3167

Keywords:

Covid-19; Curcumin, Efek Potensial

Abstract

COVID-19 telah menjadi perhatian dunia karena jumlah kematian yang terus meningkat. Pencarian pengobatan yang efisien masih terus dilakukan hingga saat ini. Respon kompleks dan multifaktorial ini memerlukan pendekatan terapeutik yang komprehensif, memungkinkan integrasi dan penyempurnaan respons terapeutik dari senyawa tunggal tertentu yang memiliki beberapa potensi aksi. Untuk itu ulasan studi ini bertujuan untuk memahami struktur serta pemahaman berbagai peran curcumin sebagai potensi terapi penderita COVID-19. Studi ini menunjukkan bahwa curcumin memiliki potensi sebagai anti viral, dan memiliki potensi pada terapi post COVID-19. Oleh karena itu, curcumin dapat menjadi pilihan terapi potensial untuk pasien COVID-19 dan studi ini juga menunjukkan bahwa diperlukan lebih banyak penelitian dan pengembangan klinis untuk menyiapkan obat baru untuk COVID-19.

References

Abdollahi, E., Momtazi, A. A., Johnston, T. P., & Sahebkar, A. (2018). Therapeutic effects of curcumin in inflammatory and immune-mediated diseases: A nature-made jack-of-all-trades? Journal of Cellular Physiology, 233(2), 830–848. https://doi.org/10.1002/jcp.25778

Ahn, K. S., Sethi, G., Jain, A. K., Jaiswal, A. K., & Aggarwal, B. B. (2006). Genetic deletion of NAD(P)H:Quinone oxidoreductase 1 abrogates activation of nuclear factor-kappaB, IkappaBalpha kinase, c-Jun Nterminal kinase, Akt, p38, and p44/42 mitogen-activated protein kinases and potentiates apoptosis. The Journal of Biological Chemistry, 281(29), 19798–19808. https://doi.org/10.1074/jbc.M601162200

Anand, P., Kunnumakkara, A. B., Newman, R. A., & Aggarwal, B. B. (2007). Bioavailability of curcumin: Problems and promises. Molecular Pharmaceutics, 4(6), 807–818. https://doi.org/10.1021/mp700113r

Bolken, T. C., & Hruby, D. E. (2008). Discovery and development of antiviral drugs for biodefense: Experience of a small biotechnology company. Antiviral Research, 77(1), 1–5.

Chen, B., Zhang, D. P., & Gao, W. (2008). Effect of curcumin on the expression of collagen type I protein and transforming growth factor-beta1 mRNA in pulmonary fibrosis rats]. Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi, 26(5), 257–261.

Chen, T.-Y., Chen, D.-Y., Wen, H.-W., Ou, J.-L., Chiou, S.-S., Chen, J.-M. Hsu, W.-L. (2013). Inhibition of enveloped viruses infectivity by curcumin. PLoS One, 8(5), e62482.

Elena, S. F., & Sanjuán, R. (2005). Adaptive value of high mutation rates of RNA viruses: Separating causes from consequences. Journal of Virology, 79(18), 11555–11558.

Hoffmann M., Kleine-Weber H., Schroeder S., Krüger N., Herrler T., Erichsen S., Schiergens T., Herrler G., Wu N., Nitsche A. SARS-CoV-2 cell entry depends on ACE2 and TMPRSS2 and is blocked by a clinically proven protease inhibitor. Cell. 2020;181(2):271–280.

Iranshahi, M., Sahebkar, A., Takasaki, M., Konoshima, T., & Tokuda, H. (2009). Cancer chemopreventive activity of the prenylated coumarin, umbelliprenin, in vivo. European Journal of Cancer Prevention, 18(5), 412–415. https://doi.org/10.1097/CEJ.0b013e32832c389e

Jager, R., Lowery, R. P., Calvanese, A. V., Joy, J. M., Purpura, M., & Wilson, J. M. (2014). Comparative absorption of curcumin formulations. Nutrition Journal, 13, 11. https://doi.org/10.1186/1475-2891-13-11

Khaerunnisa, S., Kurniawan, H., Awaluddin, R., Suhartati, S., & Soetjipto, S. (2020). Potential inhibitor of COVID-19 main protease (Mpro) from several medicinal plant compounds by molecular docking study. Preprints, 2020030226. https://doi.org/10.20944/preprints202003.0226.v1

Maurya V.K., Kumar S., Prasad A.K., Bhatt M.L., Saxena S.K. Structure-based drug designing for potential antiviral activity of selected natural products from Ayurveda against SARS-CoV-2 spike glycoprotein and its cellular receptor. Virus Disease. 2020;31(2):179–193.

Mathew, D., & Hsu, W.-L. (2018). Antiviral potential of curcumin. Journal of Functional Foods, 40, 692–699.

Mollazadeh, H., Cicero, A. F. G., Blesso, C. N., Pirro, M., Majeed, M., & Sahebkar, A. (2019). Immune modulation by curcumin: The role of interleukin-10. Critical Reviews in Food Science and Nutrition, 59(1), 89–101. https://doi.org/10.1080/10408398.2017.1358139

Obata, K., Kojima, T., Masaki, T., Okabayashi, T., Yokota, S., Hirakawa, S., Tanaka, S. (2013). Curcumin prevents replication of respiratory syncytial virus and the epithelial responses to it in human nasal epithelial cells. PLoS One, 8(9), e70225

Panahi, Y., Hosseini, M. S., Khalili, N., Naimi, E., Simental-Mendía, L. E., Majeed, M., & Sahebkar, A. (2016). Effects of curcumin on serum cytokine concentrations in subjects with metabolic syndrome: A post-hoc analysis of a randomized controlled trial. Biomedicine and Pharmacotherapy, 82, 578–582. https://doi.org/10.1016/j.biopha.2016.05.037

Panahi, Y., Kianpour, P., Mohtashami, R., Jafari, R., Simental-Mendía, L. E., & Sahebkar, A. (2017). Efficacy and safety of phytosomal curcumin in nonalcoholic fatty liver disease: A randomized controlled trial. Drug Research, 67(4), 244–251. https://doi.org/10.1055/s-0043-100019

Praditya, D., Kirchhoff, L., Brüning, J., Rachmawati, H., Steinmann, J., & Steinmann, E. (2019). Anti-infective properties of the golden spice curcumin. Frontiers in Microbiology, 10, 912.

Puar, Y. R., Shanmugam, M. K., Fan, L., Arfuso, F., Sethi, G., & Tergaonkar, V. (2018). Evidence for the involvement of the master transcription factor NF-?B in cancer initiation and progression. Biomedicine, 6(3), 82. https://doi.org/10.3390/biomedicines6030082

Rezaee, R., Momtazi, A. A., Monemi, A., & Sahebkar, A. (2017). Curcumin: A potentially powerful tool to reverse cisplatin-induced toxicity. Pharmacological Research, 117, 218–227. https://doi.org/10.1016/j.phrs. 2016.12.037

Sahebkar, A. (2010). Molecular mechanisms for curcumin benefits against ischemic injury. Fertility and Sterility, 94(5), e75–e76. https://doi.org/ 10.1016/j.fertnstert.2010.07.1071

Sahin, A. R., Erdogan, A., Agaoglu, P. M., Dineri, Y., Cakirci, A. Y., Senel, M. E., … Tasdogan, A. M. (2020). 2019 novel coronavirus (COVID-19) outbreak: A review of the current literature. EJMO, 4 (1), 1–7.

Sun, L., Xing, Y., Chen, X., Zheng, Y., Yang, Y., Nichols, D. B. Baker, S. C. (2012). Coronavirus papain-like proteases negatively regulate antiviral innate immune response through disruption of STING-mediated signaling. PLoS One, 7(2), e30802.

Ting, D., Dong, N., Fang, L., Lu, J., Bi, J., Xiao, S., & Han, H. (2018). Multisite inhibitors for enteric coronavirus: Antiviral cationic carbon dots based on curcumin. ACS Applied Nano Materials, 1(10), 5451–5459.

Utomo, R. Y., & Meiyanto, E. (2020). Revealing the potency of citrus and galangal constituents to Halt SARS-CoV-2 infection. Preprints, 2020030214. https://doi.org/10.20944/preprints202003.0214.v1

Wen, C.-C., Kuo, Y.-H., Jan, J.-T., Liang, P.-H., Wang, S.-Y., Liu, H.-G. Lee, S.-S. (2007). Specific plant terpenoids and lignoids possess potent antiviral activities against severe acute respiratory syndrome coronavirus. Journal of Medicinal Chemistry, 50(17), 4087–4095.

Yang, K. Y., Lin, L. C., Tseng, T. Y., Wang, S. C., & Tsai, T. H. (2007). Oral bioavailability of curcumin in rat and the herbal analysis from Curcuma longa by LC-MS/MS. Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences, 853(1-2), 183–189. https://doi.org/10.1016/j.jchromb.2007.03.010

Zumla, A., Chan, J. F., Azhar, E. I., Hui, D. S., & Yuen, K.-Y. (2016). Coronaviruses-Drug discovery and therapeutic options. Nature Reviews Drug Discovery, 15(5), 327–347

Downloads

Published

29-12-2021

How to Cite

Hidayati, N. R. ., Nisa, I. K. ., Darmawan, A. ., & Nisa, F. (2021). Efek Potensial Senyawa Curcumin sebagai Terapi pada Penderita Covid-19: Literature Review. Jurnal Pendidikan Tambusai, 5(3), 11368–11373. https://doi.org/10.31004/jptam.v5i3.3167

Issue

Vol. 5 No. 3 (2021): 2021

Section

Articles of Research

Citation Check

License

Copyright (c) 2021 Nur Rahmah Hidayati, Ikrima Khaerun Nisa, Arief Darmawan, Fitrotun Nisa

Creative Commons License

This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.

Authors who publish with this journal agree to the following terms:

  • Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work’s authorship and initial publication in this journal.
  • Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal’s published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
  • Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).